A statement says she died on Tuesday following complications from a recent urinary tract infection.

The cat from Arizona had "helped millions of people smile".

Grumpy, whose real name was Tardar Sauce, went viral in 2012 after photographs of her sour expression emerged online. Her image quickly spread as a meme.

According to owner Tabitha Bundesen, her facial expression was caused by feline dwarfism and an underbite.

Grumpy Cat travelled the world making television appearances and in 2014 even starred in her own Christmas film.

Madame Tussauds in San Francisco unveiled a waxwork of her in 2015.

Her Instagram account has more than two million followers.

Grumpy's face has starred in thousands of memes with many people choosing to share them again after hearing the news of her death.

Others simply paid tribute.In 2018, her owners won a $710,000 (£555,000) payout in a copyright lawsuit.

Grumpy Cat Limited sued the owners of the US coffee company Grenade for exceeding an agreement over the cat's image.

The company only had rights to use the cat to sell its "Grumppuccino" iced drink, but was also selling other Grumpy products.

Ms Bundesen previously worked as a waitress before her beloved pet gained internet stardom. She told the Express newspaper that she quit her job "within days" of Grumpy's first appearance on social media.