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The government may have to rethink its tax-cutting plans to reassure financial markets and stabilise the economy, some senior Conservative MPs have said.
The warnings came ahead of a bruising appearance for the prime minister at a meeting of Tory backbenchers.
One loyal minister told the BBC: "We are completely in a dreadful place. There is no way out - maybe Liz Truss will find a way, but I cannot see it."
Ms Truss has repeatedly defended the proposed tax cuts outlined last month.
The chancellor's mini-budget on 23 September, which included £45bn of tax cuts funded by borrowing, sparked turmoil on financial markets and prompted the Bank of England to intervene to protect pension funds.
Kwasi Kwarteng is due to set out how he will fund the package and reduce debt on 31 October.
Ms Truss insists cancelling a rise in corporation tax from 19% to 25% due in April and other tax cuts will help boost growth.
The prime minister also believes stepping back from what she describes as the highest tax burden in 70 years would allow the public to keep more of the money they earn at a time of global high prices.
One of the ways the government plans to achieve this is by bringing forward a 1p cut in the lower rate of income tax, so people will be taxed 19% on earnings between £12,571 and £50,270.
But the editor of Conservative Home Paul Goodman has argued the mini-budget is now "more likely than not" to be totally withdrawn.
Mr Goodman told BBC Radio 4's Today programme he was not sure Conservative ministers and MPs were "capable of putting together a package of public spending cuts on the scale required" to balance the books.
"And if they do, whether [the cuts] are going be acceptable to the markets," he added. "Or whether the markets are now going to demand the withdrawal, in effect, of the mini-budget."
Ms Truss has denied she is planning public spending cuts, saying the government would instead focus on reducing debt "by making sure we spend public money well".
However, Mel Stride, a prominent backer of Ms Truss's leadership rival Rishi Sunak, suggested the government would need to show a "clear change of tack" to restore credibility with the financial markets.
"Given the clear government position expressed today on protecting public spending there is an emerging question. Whether any plan that does not now include at least some element of further row back on the tax package can actually satisfy the markets," he said.
Earlier, he told the Commons he believed it was "quite possible" the chancellor would have to make more changes to the tax cuts announced in his mini-budget.
Asked to confirm whether this possibility was still on the table, Treasury Minister Chris Philp replied: "There are not any plans to reverse any of the tax measures announced in the growth plan."
Tory MP Kevin Hollinrake, who was also a Sunak supporter, said it would be better for the chancellor to U-turn on aspects of his mini-budget rather than cause more market turmoil.
"I think it's better to have looked at this more carefully in the context of what's happened over the last few weeks and say 'I think we've got some of this wrong and these tax cuts need to be introduced over time'," he told BBC Radio 4's World at One programme.
He suggested reversing the government's decision to scrap the planned hike in corporation tax was one potential option.
Meanwhile, former deputy prime minister Damian Green said an obvious way to reduce debt while ruling out public spending cuts would be to defer some tax cuts.
He told BBC Radio 4's PM programme the reversal of some parts of the mini-budget was being discussed openly by Tory MPs.
Former Conservative minister David Davis suggested overturning some of the tax cuts would "buy some time" and persuade Tory critics to "come in behind them".
He told ITV's Peston the mini-budget was a "maxi-shambles" but he did not think there would be moves to replace the prime minister in the next few months as the party would have "zero chance" of winning an election if it was in a "civil war".
The government has already U-turned on its plan to scrap the top rate of income tax, following market turmoil and vocal opposition from some Tories.
However, this only made up £2bn of the tax cuts announced by the chancellor.
On Wednesday evening, Ms Truss faced sharp criticism from some of her own MPs during a meeting of the 1922 Committee of backbenchers.
Sources in the room told the BBC that Robert Halfon had accused Ms Truss of "trashing blue collar conservatism".
He told her the party's record over the past 10 years had included things like boosting apprenticeships and the living wage, whereas she had cut tax for millionaires and wanted to cut affordable housing and benefits.
MPs who were present said he got a cheer, while Ms Truss looked "shocked" and said he could come to speak to her.
They said another Tory MP, James Cartlidge, also criticised the government's mini-budget, saying the communication had been poor and she had not prepared the markets.
Both MPs supported Mr Sunak during the Tory leadership election.
The BBC's Nick Watt said he encountered a "wall of derision and unease" about the prime minister outside the room.
The loyal minister also told him: "It's like Black Wednesday in 1992, when interest rates shot up, we lost economic credibility, and it took us 15 years to get it back."
However, leaving the meeting the prime minister said it had been "very good".
One MP who supported Ms Truss in the leadership race said the PM acknowledged during the meeting that she could have laid the ground better for her recent policies.
During the initial election rounds most MPs did not back Ms Truss to become one of the final two in the contest. She won based on a final vote among party members.
