The 26-year-old number eight missed the autumn internationals after the injury to his left arm, which needed surgery.

Sarries wingers Liam Williams and David Strettle and scrum-half Richard Wigglesworth are also back from injury.

Sale make just one change to the side that beat Gloucester 30-15, bringing in number eight Josh Strauss.

He comes in for Jean Luc du Preez, who picked up a groin injury in the win at Kingsholm.

The return of Vunipola will provide a boost to England coach Eddie Jones ahead of the Six Nations, with England starting their campaign with a visit to defending champions Ireland on 2 February (16:45 GMT).

Wales winger Williams has been sidelined with a hamstring issue, with Wigglesworth also returning after missing recent fixtures with a groin problem.

Prop Vincent Koch, hooker Tom Woolstencroft and flanker Schalk Burger are back in the Saracens pack.

Second-placed Sarries start round 11 one point behind league leaders Exeter Chiefs, while Sale are seventh, three points off the top four.

Sale: Ashton; Solomona, O'Connor, James, McGuigan; du Preez, de Klerk; Harrison, Webber, John, Beaumont, Phillips, Ross (capt) Curry, Strauss.

Replacements: Langdon, Bristow, Jones, Evans, Curry, Cliff, James, Reed.

Saracens: Goode; Williams, Tompkins, Lozowski, Strettle; Farrell (capt), Wigglesworth; M Vunipola, Woolstencroft, Koch, Skelton, Kruis, Isiekwe, Burger, B Vunipola.

Replacements: Tolofua, Barrington, Lamositele, Clark, Wray, Spencer, Bosch, Maitland.

Referee: Matthew Carley.