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Holders Borussia Dortmund were knocked out of the German Cup on Tuesday when they suffered a shock last-16 defeat to second division side St Pauli.
The Bundesliga 2 leaders struck early in the first half when Etienne Amenyido finished from close range.
A strong Dortmund side fell further behind in the 40th minute when Axel Witsel turned a cross into his own net.
Erling Braut Haaland reduced the deficit from the penalty spot but St Pauli held on for a famous win.
Dortmund's Bundesliga rivals Cologne also went out to second-tier opposition, losing on penalties to Hamburg SV after the game ended 1-1, while Bochum beat Mainz 3-1.
