Russia has been handed a four-year ban from all major sporting events by the World Anti-Doping Agency (Wada).
It means the Russia flag and anthem will not be allowed at events such as the Tokyo 2020 Olympics and Paralympics and football's 2022 World Cup in Qatar.
But athletes who can prove they are untainted by the doping scandal will be able to compete under a neutral flag.
Wada's executive committee made the unanimous decision in a meeting in Lausanne, Switzerland.
It comes after Russia's Anti Doping Agency (Rusada) was declared non-compliant for manipulating laboratory data handed over to investigators in January 2019.
It had to hand over data to Wada as a condition of its controversial reinstatement in 2018 after a three-year suspension for its vast state-sponsored doping scandal.
Wada says Rusada has 21 days to appeal against the ban. If it does so, the appeal will be referred to the Court of Arbitration for Sport (Cas).
Wada president Sir Craig Reedie said the decision showed its "determination to act resolutely in the face of the Russian doping crisis".
He added: "For too long, Russian doping has detracted from clean sport. The blatant breach by the Russian authorities of Rusada's reinstatement conditions demanded a robust response.
"That is exactly what has been delivered.
"Russia was afforded every opportunity to get its house in order and re-join the global anti-doping community for the good of its athletes and of the integrity of sport, but it chose instead to continue in its stance of deception and denial."
But Wada vice-president Linda Helleland said the ban was "not enough".
"I wanted sanctions that can not be watered down," she said. "We owe it to the clean athletes to implement the sanctions as strongly as possible."
A total of 168 Russian athletes competed under a neutral flag at the 2018 Winter Olympics in Pyeongchang after the country was banned following the 2014 Games, which it hosted in Sochi. Russian athletes won 33 medals in Sochi, 13 of which were gold.
Russia has been banned from competing as a nation in athletics since 2015.
Despite the ban, Russia will be able to compete at Euro 2020 - in which St Petersburg will be a host city - as European football's governing body Uefa is not defined as a 'major event organisation' with regards to rulings on anti-doping breaches.
In a statement, the International Paralympic Committee (IPC) said: "Those responsible for the manipulation of data from the Moscow laboratory before it was transferred to Wada appear to have done everything possible to undermine the principles of fair and clean sport, principles that the rest of the sporting world support and adhere to.
"This sincere lack of respect towards the rest of the global sporting movement is not welcome and has zero place in the world of sport. It is only right that those responsible for this data manipulation are punished."
Rusada was initially declared non-compliant in November 2015 after a Wada-commissioned report by sports lawyer Professor Richard McLaren alleged widespread corruption that amounted to state-sponsored doping in Russian track and field athletics.
A further report, published in July 2016, declared Russia operated a state-sponsored doping programme for four years across the "vast majority" of summer and winter Olympic sports.
In 2018, Wada reinstated Rusada as compliant after the national agency agreed to release data from its Moscow laboratory from the period between January 2012 and August 2015.
However, positive findings contained in a version courtesy of a whistleblower in 2017 were missing from the January 2019 data, which prompted a new inquiry.
Wada's compliance review committee (CRC) recommended a raft of measures based "in particular" on a forensic review of inconsistencies found in some of that data.
As part of the ban, Russia may not host, or bid for or be granted the right to host any major events for four years, including the 2032 Olympic and Paralympic Games.