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A statement issued by the Normalization Committee of the Ghana Football Association (GFA) quoted unnamed officials of Inter as saying Asamoah's knee injury "has been intermittent and there is the need to seek urgent medical attention".
However, the 29-year-old was on Wednesday pictured alongside other Inter Milan players who are not on international duty jogging in training.
Asamoah reportedly had a swollen knee in the aftermath of Inter's 4-1 away loss against Atlanta in the Italian Serie A on Sunday but showed no ill effects yesterday as he was put through his paces by Inter coach Luciano Spalleti.
Asamoah and his Inter teammates including Radja Nainggolan, Keita Balde, Borja Valero and Samir Handanovi? participated in some gym and pitch drills.
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Black Stars coach Kwasi Appiah decided not to call-up a replacement after Asamoah's injury.
His withdrawal from the Ghana team means the Black Stars will now play the Walia Ibex of Ethiopia with 19 players in a must-win clash on November 18.
Ghana Squad:
Goalkeepers: Richard Ofori (Martizburg, South Africa) Lawrence Ati (Sochaux, France)
Defenders: Harrison Afful (Columbus Crew, USA) John Boye (FC Metz, France) Lumor Agbenyenu (Sporting CP, Portugal) Andy Yiadom (Reading Football Club, England) Jonathan Mensah (Columbus Crew, USA) Kassim Nuhu (TSG Hoffenheim, Germany)
Midfielders: Andre Ayew (Fenerbahce, Turkey) Mubarak Wakaso (Alaves, Spain) Kwadwo Asamoah (Inter Milan, Italy) Afriyie Acquah (Empoli,Italy) Christian Atsu (Newcastle, England) Nana Ampomah (Waasland-Beveren, Belgium) Thomas Partey (Atlético Madrid) Majeed Ashimeru (St. Gallen, Switzerland)
Forwards: Jordan Ayew (Crystal Palace, England) Asamoah Gyan (Kayserispor, Turkey) Majeed Waris (FC Nantes, France) Emmanuel Boateng (Levante, Spain).
