Jack Leach will return home from England's tour of South Africa following the left-arm spinner's struggle with illness.
Leach missed the final Test against New Zealand in November with sepsis and has not featured in South Africa after suffering gastroenteritis and flu.
"Jack hasn't been able to get 100% fit," head coach Chris Silverwood said.
"His focus has to be getting himself better, which is best served back in England without any distractions."
Leach, who also has Crohn's Disease, will fly home on Thursday.
"I have no doubt he will return to full fitness in the medium term and hopefully he will recover in time for our tour of Sri Lanka in March," Silverwood added.
"He is a great lad to have around the squad and his infectious personality and popularity will be missed."
The third Test begins in Port Elizabeth on Thursday, with the four-match series level at 1-1.