Crystal Palace forward Eberechi Eze faces being out for at least six months after suffering a "serious injury" following a "freak" training incident.
Eze injured his Achilles after making a sharp turn in training and went down without a challenge, with an MRI scan confirming the extent of the injury.
The 22-year-old has impressed since joining from QPR for £19.5m, scoring four goals in 36 games this season.
"It is devastating, particularly for him," Hodgson told BT Sport.
"He has had a good season and such a good start to his Premier League career, getting better and better and is such a good guy as well.
"He is an important member of the team and to see that happen in a freak situation, it is almost impossible to understand how it happened. Then for it to be such a serious injury, we are all absolutely devastated for him. He is a resilient young man and will come back strongly."