Eddy Pineiro's overtime field goal earned the San Francisco 49ers a dramatic 26-23 win over the Los Angeles Rams at the SoFi Stadium in Inglewood, California.

Pineiro's 41-yard score - his fourth of the game - went over via the inside of the left post with less than six minutes remaining.

Deommodore Lenoir and Marques Sigle then combined to deny Rams running back Kyren Williams on the fourth down as the hosts pushed for a late game-levelling score.

Rams had earlier forced overtime thanks to a 48-yard field goal from kicker Joshua Karty with two seconds left in regulation.

It was a battling win for the 49ers, who were without a host of players through injury, including quarterback Brock Purdy and wide receivers Jauan Jennings and Ricky Pearsall.

Purdy's replacement, Mac Jones, overcame a knee injury and arm and leg cramps, completing 33 of 49 passes for 342 yards and two touchdowns.

"It came down to who was going to be the toughest team, and I think it was us," Jones said.

The 49ers, who suffered their first defeat of the season against the Jacksonville Jaguars last week, improve to 4-1 and sit top of of the NFC West.

"I can't say enough about the guys, they were unbelievable," 49ers coach Kyle Shanahan said.

"That was a huge character win."