England clinched their place at next year's finals in dramatic style, while Germany have been relegated to the second tier. Northern Ireland are also down, but Scotland could be promoted.
The Nations League group stage comes to an end in this international break, which runs until Tuesday, with nine important spots left to decide.
Twenty-four of the 28 group winners, promotion and relegation places have been decided so far.
England won their group on Sunday after a late turnaround in their winner-takes-all match against Croatia, and join Portugal in next year's finals. Switzerland had an even more remarkable turnaround, coming back to beat Belgium 5-2 to take the third final spot.
Northern Ireland and the Republic of Ireland both drop into the third tier, while Scotland could go in the other direction. Wales cannot be promoted or relegated from League B.
In the bottom tier, Belarus have clinched a Euro 2020 play-off place and Kosovo could join them.
BBC Sport talks you through who has secured what and the permutations for the remaining big games are.
League A
Booked place in June 2019 finals and Euro 2020 play-offs - Portugal, England, Switzerland, Netherlands
Relegated to League B - Germany, Iceland, Poland, Croatia
League B
Promoted to League A, and Euro 2020 play-off spot - Ukraine, Denmark, Bosnia-Herzegovina
Relegated to League C - Northern Ireland, Republic of Ireland, Turkey, Slovakia
Sweden and Russia are still in contention for the last promotion spot
League C
Promoted to League B, and Euro 2020 play-off spot - Finland, Norway
Relegated to League D - Lithuania, Slovenia, Estonia
Israel, Scotland, Romania and Serbia are still in contention for the last two promotion spots
League D
Promoted to League C, and Euro 2020 play-off spot - Georgia, Belarus, Macedonia
Kosovo and Azerbaijan are still in contention for the last promotion spot
England were five minutes away from being relegated to League B - but instead were promoted after their thrilling win over Croatia.
With 12 minutes remaining, Croatia looked set to win the group as they held a 1-0 lead at Wembley. Jesse Lingard's equaliser put Spain back into top spot in the group but in the 85th minute Harry Kane fired England to the top - and relegated Croatia.
England will be in a group of five, and not six, teams for Euro 2020 qualifying. The Nations League finalists will all be in smaller groups because they will not be free in June for qualifiers.
Denmark have been promoted to League A while the Republic of Ireland have been relegated to League C. Wales remain in League B
Denmark's 2-1 win over Wales on Friday saw them win promotion and relegate the Republic of Ireland.
Wales would have been promoted had they beaten the Danes but are now guaranteed second place - which means they will remain in League B.
They could still reach the Euro 2020 play-offs, depending on who qualifies next year.
The Republic of Ireland needed Wales to win to keep their survival hopes alive, but they drop down to League C after Sunday's game in Aarhus.
Monday's final game could have been seen as a dead rubber, although the Republic claimed a 0-0 draw in Denmark.
If Nations League group winners qualify for Euro 2020 through next year's qualifiers, their play-off spot goes to the next highest-ranked team in their league who did not qualify.
Northern Ireland finished bottom of their group without a point after an injury-time defeat by Austria in their final game.
Michael O'Neill's side had been relegated on Thursday when Austria drew 0-0 with promoted Bosnia-Herzegovina.
They could still end up in the Euro 2020 play-offs if most of the other teams in League B qualify automatically for the tournament next year.
Scotland v Israel (Tuesday, 20 November - 19:45 GMT)
Scotland can still win promotion, but have avoided relegation
Scotland will be promoted to the second tier of the competition - and guarantee a Euro 2020 play-off spot - if they beat Israel at home.
Victory in Albania on Saturday means Scotland will not be relegated. Yet Albania, curiously, will avoid relegation too because of a quirk in League C's set-up.
That is because Group C1 is the only one in League C with three teams - all the rest have four sides. And while the bottom sides in Groups C2, C3 and C4 are definitely relegated, the fourth relegation spot to League D goes to the worst third-placed team across the four groups (excluding results against fourth-placed teams), rather than automatically to the bottom team in Group C1.
Germany have only won one of their past seven competitive games
England, Portugal and Switzerland have qualified for next year's finals, which will be held in Portugal, with France joining them on Monday night.
Portugal's 0-0 draw in Italy on Saturday took them through, with Poland relegated to the second tier.
Germany were relegated to League B after picking up only two points from four games - their fate confirmed by the Netherlands' 2-0 win over world champions France on Friday.
The Netherlands' draw with Germany on Monday saw them top the group ahead of France.
Netherlands finish top of Group A1 above France on goal difference while Germany are relegated to the second tier
England's 2-1 win over Croatia relegated the World Cup finalists, while Spain are neither in the finals nor relegated.
Switzerland needed four goals to progress when they trailed 2-0 to Belgium on Sunday - and they scored five to overtake the Red Devils for top spot and a place in the finals.
Ukraine, Bosnia and Denmark have already guaranteed promotion to the top division, while Russia are in pole position to take the other slot.
Kosovo were only elected to Uefa and Fifa in 2016
The unique way the Nations League is run means four of Europe's bottom 16 will make the Euro 2020 play-offs - and one will qualify for the tournament.
Georgia have taken a spot, as well as winning promotion, by winning their group. Belarus joined them with a 2-0 win at San Marino in their final game.
Kosovo are two points clear of Azerbaijan with one game left, while Macedonia only need a point against Gibraltar on Monday to win the other group.
San Marino are the only team in the bottom league not to pick up a point, but luckily for them relegation is impossible as there is no fifth league for anybody to drop into.