Lautaro Martinez gave Inter the lead with a deflected strike before Lukaku ran down the right wing, cut inside and smashed home from 25 yards.

Milan Skriniar's own goal gave Brescia hope but Antonio Conte's Inter held on.

Lukaku, who joined Inter from Manchester United for £74m in the summer, has scored seven goals in 10 league games this season.

Perennial champions Juventus - who have yet to lose in the league - will go back to the top if they beat Genoa on Wednesday.