Ahmed Mogni doubled the lead before the Black Stars fought back to make it 2-2.

However, Mogni tapped in his second in the 85th minute to inflict Ghana's first group-stage exit since 2006.

The result in Group C will go down as one of the biggest shocks in Nations Cup history as Comoros scored at the finals for the first time and then went on to record their maiden victory.

Incredibly, the side ranked 132nd in the world now have a chance to reach the knockout stages as one of four best-ranked third-placed sides even though the Coelacanths lost their first two games in Cameroon.

The tiny island nation with just under a million inhabitants - and more famous for its history of political coups than its football - had only won its first Nations Cup or World Cup qualifier in 2016 at the 20th attempt.

A squad bolstered by members of the diaspora, with many plying their trade in the lower leagues in France, lost just once to achieve a maiden qualification and Comoros have now beaten one of the continent's giants.

Ghana had put in disjointed displays in their first two games, a 1-0 defeat by Morocco and a niggly 1-1 draw with Gabon, and finish bottom of the group table despite putting in a spirited display following Ayew's 25th-minute sending off.

Their fans in the Roumde Adjia Stadium in Garoua looked stunned at the full-time whistle, being left to contemplate a rollercoaster second half which ended their bid for a first Nations Cup title since 1982.

Their exit will increase the pressure on coach Milovan Rajevac, who returned for a second spell in charge in September.

The Serb led the Black Stars to the Nations Cup final in 2010 and the World Cup quarter-finals the same year, and guided the West Africans through to Africa's play-offs for this year's World Cup.

However, Ghana only won their qualifying group ahead of South Africa on goals scored and are unseeded for the play-off draw - where they will face one of Senegal, Morocco, Tunisia, Algeria and Nigeria for a place in Qatar.

Comoros, meanwhile, celebrated their three points heartily and now await the final round of matches in the remaining three groups to see if their stunning victory can extend their stay at the tournament.

VAR decision leaves Ghana reeling

Ghana had needed a win to have a chance of a spot in the last 16 and made the worst possible start by conceding in the fourth minute.

Ibroihim Youssouf was released down the right before finding Ben Nabouhane in the middle, and the Comoros skipper sent a low left-footed shot into the bottom right-hand corner from the edge of the area.

Kamaldeen Sulemana tested Comoros keeper Salim Ben Boina with two shots from outside the area, the second of which provided another turning point in the contest.

Ben Boina spilled the winger's shot and Ayew went in strongly in an attempt to win the loose ball.

Andre Ayew's red card left Ghana facing an uphill task

The coming together injured the keeper and the Ghana captain looked surprised to be shown red following a video assistant referee review, with replays showing he went in with studs up and made contact with Ben Boina's upper arm.

The Comoros keeper was injured in the clash and forced off, leading to the introduction of Ali Ahamada, who came into the tournament without a club side.

Black Stars rally but ultimately denied

The islanders made it 2-0 just after the hour mark as Mogni twisted and turned the Ghana defence on the edge of the area before sending a low shot past Jojo Wollacott and into the bottom right-hand corner.

The strike sparked a group celebration down by the corner-flag involving substitutes - but Ghana immediately stirred.

Richmond Boakye looped in a header from a corner and, after Ahamada had clawed away two threatening balls in from Daniel-Kofi Kyereh, Ghana levelled in the 77th minute from another set piece.

Arsenal midfielder Thomas Partey flicked on a corner and Alexander Djiku was on hand to convert from close range to give the Black Stars renewed hopes of going through.

But those dreams were dashed five minutes from time when Bendjaloud Youssouf cut the ball back for Mogni to seal a famous win for Comoros.

Ghana, who appear to lack leaders of the calibre of Asamoah Gyan, the striker who led them to the last eight at the World Cup 12 years ago, now face the challenge of regrouping before March's World Cup play-offs.

Thomas Partey took over as Ghana captain following Andre Ayew's sending off, but the midfielder endured a frustrating evening