It had seemed that Newcastle were preparing to soften the blow of Isak's departure by signing Benjamin Sesko from RB Leipzig.
However, he ultimately chose to join Manchester United in a move worth £73.7m.
The 22-year-old scored 39 goals in 87 games in all competitions at RB Leipzig, with 27 of those coming in 64 Bundesliga appearances.
Sesko is the top goalscorer currently aged under 23 in Europe's top five leagues, in all competitions and Rooney believes it could well prove to be one of the best Premier League deals of the summer.
"I really like Sesko," he said.
"I think he will be top. He has all the attributes, he is big, he can head the ball, he is strong, he is quick and uses both feet. But going to Manchester United is different to going anywhere and there is a big pressure."
Another signing he is expecting big things from is Viktor Gyokeres, who joined Arsenal from Sporting this summer.
"I played against Gyokeres when he was at Coventry," Rooney said.
"He has been in England, he knows the culture but it is a different level and the pressure on him going to Arsenal, who have not had a forward for so many years, is huge.
"The big plus is I think Arsenal fans will love him. He works hard, he plays with a lot of energy, he likes to put a tackle in and can score goals."
Sesko became United's third major signing in attack following the arrivals of Matheus Cunha for £62.5m and Bryan Mbeumo for £65m with £6m in add-ons.
For Rooney, it has been a much-needed refresh of the United attack as they look to significantly improve on last season's 15th-placed finish in the Premier League.
But the 39-year-old believes a midfielder still needs to be brought in to ensure his former side are in the best position to compete higher up the table once more.
They have been linked with Brighton midfielder Carlos Baleba.
"They had to change the attack," Rooney said.
"The attacking players looked like they had lost a lot of confidence and some looked like they didn't want to be there. Fair play to Ruben Amorim because he has dealt with that and he is trying to move all those players on.
"The attacking players they have brought in will make a big difference. I'd still like to see a holding midfield player. That is where hopefully, towards the end of the window, they improve that.
"He [Baleba] is an incredible player. He is physically very strong, he is good on the ball.
"Manchester United just need someone in who will help break up the play and let those attacking players go and win them games."