Ghanaian representatives Medeama SC and Nations FC have learned their opponents for the preliminary rounds of the 2026/27 CAF inter-club competitions following Thursday's draw at the Confederation of African Football (CAF) headquarters in Cairo, Egypt.

Premier League champions Medeama have been handed a first-round tie against Congolese giants TP Mazembe in the TotalEnergies CAF Champions League.

The Tarkwa-based side will host the first leg at the TnA Stadium before travelling to the Democratic Republic of Congo for the return fixture. Should Medeama overcome the five-time African champions, they will face either Tunisia's Club Africain or Mali's Djoliba AC in the second preliminary round.

In the TotalEnergies CAF Confederation Cup, MTN FA Cup winners Nations FC have been drawn against Mali's FC Diarra.

The Kumasi-based club will travel to Mali for the first leg, scheduled for September 4–6, 2026, before hosting the return leg in Ghana between September 11 and 13.

Nations FC will take on the winner of the tie between Niger's AS Zam and Togo's ASKO de Kara in the second preliminary round, if they progress.

Nations FC secured their place in the CAF Confederation Cup after lifting the 2025/26 MTN FA Cup, earning a historic first qualification for African club football.