The Ghana Health Service (GHS) has recorded 25 deaths since the last quarter of 2008, in some parts of the country, a statement in Accra said on Wednesday.
The first cases were reported in the Accra Metropolitan area.
"The situation has become a bit worrisome with similar outbreaks being reported in parts of Eastern and Volta regions," said the statement signed by Dr Elias Sory, Director-General of GHS.
Giving the breakdown of the cases and related deaths, the statement said the Accra Metropolitan area in Greater Accra recorded a total of 1,112 cases, resulting in seven deaths while Akuapem North in the Eastern region had 188 cases with four deaths.
In the Volta Region, Keta Municipality reported 310 cases with 11 deaths; Krachi East, 63 cases with three deaths, and Nkwanta, 17 cases without any death.
Cholera is an acute bacterial disease caused by Vibrio Cholera.
The disease is characterized by sudden onset of profuse painless watery diarrhoea, occasional vomiting, rapid dehydration, acidosis and circulatory collapse.
Cholera could be transmitted through ingestion of water contaminated with faeces, vomitus of patients, contaminated foods, fruits and vegetables.
The statement said cholera is preventable, adding that it could be effectively prevented if populations have access to adequate excreta disposal systems, potable water and safe food.